Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization
ObjectivesInflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients have high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs and ED is investigated...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342658/full |
| _version_ | 1797213501993779200 |
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| author | Dongze Liu Zheng Qin Bocun Yi Hongbo Xie Yunan Liang Liang Zhu Kuo Yang Hongtuan Zhang |
| author_facet | Dongze Liu Zheng Qin Bocun Yi Hongbo Xie Yunan Liang Liang Zhu Kuo Yang Hongtuan Zhang |
| author_sort | Dongze Liu |
| collection | DOAJ |
| description | ObjectivesInflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients have high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs and ED is investigated using the Mendelian randomization (MR) approach.MethodsSingle nucleotide polymorphisms (SNPs) exposure data of 41 ICs came from a genome-wide association study (GWAS) of 8293 subjects. At the same time, the FINNGEN R9 database provided the ED outcome data containing 2205 ED patients and 164104 controls. MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.ResultsFrom a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). Meanwhile, IP-10 (p=0.099) and IL-1RA (p=0.135) failed to demonstrate causality in reverse MR analysis.ConclusionsChanges in ICs levels will significantly affect the risk of ED, especially IP-10 as a risk component for ED and IL-1RA as a protective component for ED. In the future, we can achieve targeted treatment and prevention of ED by intervening with specific inflammatory factors. |
| first_indexed | 2024-04-24T10:59:17Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T10:59:17Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-14e2fef3a1b94a7ead04be8826b38ee62024-04-12T04:19:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-04-011510.3389/fimmu.2024.13426581342658Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomizationDongze Liu0Zheng Qin1Bocun Yi2Hongbo Xie3Yunan Liang4Liang Zhu5Kuo Yang6Hongtuan Zhang7Department of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Oncology, The Second Hospital of Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaDepartment of Urology, National Key Specialty of Urology, Second Hospital of Tianjin Medical University, Tianjin Key Institute of Urology, Tianjin Medical University, Tianjin, ChinaObjectivesInflammatory cytokines (ICs) play an important role in erectile dysfunction (ED). Previous studies have demonstrated that most ED patients have high levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8). The causality between 41 ICs and ED is investigated using the Mendelian randomization (MR) approach.MethodsSingle nucleotide polymorphisms (SNPs) exposure data of 41 ICs came from a genome-wide association study (GWAS) of 8293 subjects. At the same time, the FINNGEN R9 database provided the ED outcome data containing 2205 ED patients and 164104 controls. MR-Egger (ME), inverse variance weighting (IVW), and weighted median (WM) were applied to conduct the MR study and IVW was taken as the main criterion.ResultsFrom a genetic perspective, the increase of interferon-inducible protein-10 (IP-10) level significantly increased the risk of ED (P=0.043, odds ratio (OR)=1.269, 95% confidence interval (95%CI): 1.007-1.600), while the increase of interleukin-1 receptor antagonist (IL-1RA) markedly decreased the risk of ED (P=0.037, OR=0.768, 95%CI: 0.600-0.984). Meanwhile, IP-10 (p=0.099) and IL-1RA (p=0.135) failed to demonstrate causality in reverse MR analysis.ConclusionsChanges in ICs levels will significantly affect the risk of ED, especially IP-10 as a risk component for ED and IL-1RA as a protective component for ED. In the future, we can achieve targeted treatment and prevention of ED by intervening with specific inflammatory factors.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342658/fullinflammatory cytokineerectile dysfunctionbidirectional Mendelian randomizationIP-10IL-1ra |
| spellingShingle | Dongze Liu Zheng Qin Bocun Yi Hongbo Xie Yunan Liang Liang Zhu Kuo Yang Hongtuan Zhang Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization Frontiers in Immunology inflammatory cytokine erectile dysfunction bidirectional Mendelian randomization IP-10 IL-1ra |
| title | Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization |
| title_full | Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization |
| title_fullStr | Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization |
| title_full_unstemmed | Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization |
| title_short | Inflammatory cytokine profiles in erectile dysfunction: a bidirectional Mendelian randomization |
| title_sort | inflammatory cytokine profiles in erectile dysfunction a bidirectional mendelian randomization |
| topic | inflammatory cytokine erectile dysfunction bidirectional Mendelian randomization IP-10 IL-1ra |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342658/full |
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