Effect of Glycosphingolipids on Osteoclastogenesis and Osteolytic Bone Diseases

Effect of Glycosphingolipids on Osteoclastogenesis and Osteolytic Bone Diseases

Alterations in glycosphingolipid production results in lysosomal storage disorders associated with neurodegenerative changes. In Gauchers disease, the patients also develop osteoporosis that is ameliorated upon treatment for the underlying defect in glycosphingolipid metabolism. The role of glycos...

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Bibliographic Details
Main Authors: Adel eErsek, Anastasios eKaradimitris, Nicole eHorwood
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Endocrinology
Subjects:
Glycosphingolipids
Bone
osteoblast
osteoclast
Gauchers disease
GM3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00106/full

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