New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation

Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substitutedphenyl)ethan-1-one derivatives, which were tested against Candida species. The synthesized compounds were characte...

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Bibliographic Details
Main Authors: Hülya Karaca Gençer, Ulviye Acar Çevik, Serkan Levent, Begüm Nurpelin Sağlık, Büşra Korkut, Yusuf Özkay, Sinem Ilgın, Yusuf Öztürk
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
1,2,4-triazole
antifungal activity
ergosterol
cytotoxicity
NIH/3T3
Online Access:http://www.mdpi.com/1420-3049/22/4/507

Internet

http://www.mdpi.com/1420-3049/22/4/507

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