FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce elevated levels of activity in Fmr1 KO mice.

Bibliographic Details
Main Authors: Xiaoqin Zhan, Hadhimulya Asmara, Ning Cheng, Giriraj Sahu, Eduardo Sanchez, Fang-Xiong Zhang, Gerald W. Zamponi, Jong M. Rho, Ray W. Turner
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16250-4

Internet

https://doi.org/10.1038/s41467-020-16250-4

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