Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood
Large-scale genetic association studies have identified many trait-associated variants that influence gene expression. Here, the authors present ARCHIE, a tool for identifying sets of genes whose regulation may be related to specific complex traits.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31845-9 |
| _version_ | 1828778157297106944 |
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| author | Diptavo Dutta Yuan He Ashis Saha Marios Arvanitis Alexis Battle Nilanjan Chatterjee |
| author_facet | Diptavo Dutta Yuan He Ashis Saha Marios Arvanitis Alexis Battle Nilanjan Chatterjee |
| author_sort | Diptavo Dutta |
| collection | DOAJ |
| description | Large-scale genetic association studies have identified many trait-associated variants that influence gene expression. Here, the authors present ARCHIE, a tool for identifying sets of genes whose regulation may be related to specific complex traits. |
| first_indexed | 2024-12-11T16:36:35Z |
| format | Article |
| id | doaj.art-14f4f3a11b1c4bbd9ffc559c48723f34 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-11T16:36:35Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-14f4f3a11b1c4bbd9ffc559c48723f342022-12-22T00:58:26ZengNature PortfolioNature Communications2041-17232022-07-0113111410.1038/s41467-022-31845-9Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole bloodDiptavo Dutta0Yuan He1Ashis Saha2Marios Arvanitis3Alexis Battle4Nilanjan Chatterjee5Department of Biostatistics, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Computer Science, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Biomedical Engineering, Johns Hopkins UniversityDepartment of Biostatistics, Johns Hopkins UniversityLarge-scale genetic association studies have identified many trait-associated variants that influence gene expression. Here, the authors present ARCHIE, a tool for identifying sets of genes whose regulation may be related to specific complex traits.https://doi.org/10.1038/s41467-022-31845-9 |
| spellingShingle | Diptavo Dutta Yuan He Ashis Saha Marios Arvanitis Alexis Battle Nilanjan Chatterjee Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood Nature Communications |
| title | Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood |
| title_full | Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood |
| title_fullStr | Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood |
| title_full_unstemmed | Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood |
| title_short | Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood |
| title_sort | aggregative trans eqtl analysis detects trait specific target gene sets in whole blood |
| url | https://doi.org/10.1038/s41467-022-31845-9 |
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