Neuronal Na+ Channels Are Integral Components of Pro-Arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

Neuronal Na+ Channels Are Integral Components of Pro-Arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the subcellular/molecular arrhythmogenic trigger(s) is unc...

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Bibliographic Details
Main Authors: Przemysław B. Radwański, PharmD, PhD, Hsiang-Ting Ho, PhD, Rengasayee Veeraraghavan, PhD, Lucia Brunello, PhD, Bin Liu, PhD, Andriy E. Belevych, PhD, Sathya D. Unudurthi, PhD, Michael A. Makara, PhD, Silvia G. Priori, MD, PhD, Pompeo Volpe, PhD, Antonis A. Armoundas, PhD, Wolfgang H. Dillmann, MD, Bjorn C. Knollmann, MD, PhD, Peter J. Mohler, PhD, Thomas J. Hund, PhD, Sándor Györke, PhD
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:JACC: Basic to Translational Science
Subjects:
β-adrenergic receptor
diastolic Ca2+ release
neuronal Na+ channels
ventricular arrhythmias
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300250

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http://www.sciencedirect.com/science/article/pii/S2452302X16300250

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