Metabolic Endotoxemia, Feeding Studies and the Use of the Limulus Amebocyte (LAL) Assay; Is It Fit for Purpose?

The Limulus amebocyte assay (LAL) is increasingly used to quantify metabolic endotoxemia (ME), particularly in feeding studies. However, the assay was not intended to assess plasma at levels typically seen in ME. We aimed to optimize and validate the LAL assay under a range of pre-treatment conditio...

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Bibliographic Details
Main Authors: Karma Pearce, Dianne Estanislao, Sinan Fareed, Kelton Tremellen
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Diagnostics
Subjects:
Online Access:https://www.mdpi.com/2075-4418/10/6/428