Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders
Endomembrane alkali cation (Na+, K+)/proton (H+) exchangers (eNHEs) are increasingly associated with neurological disorders. These eNHEs play integral roles in regulating the luminal pH, processing, and trafficking of cargo along the secretory (Golgi and post-Golgi vesicles) and endocytic (early, re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.892196/full |
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| author | Andy Y. L. Gao Andy Y. L. Gao Etienne Lourdin-De Filippis John Orlowski R. Anne McKinney |
| author_facet | Andy Y. L. Gao Andy Y. L. Gao Etienne Lourdin-De Filippis John Orlowski R. Anne McKinney |
| author_sort | Andy Y. L. Gao |
| collection | DOAJ |
| description | Endomembrane alkali cation (Na+, K+)/proton (H+) exchangers (eNHEs) are increasingly associated with neurological disorders. These eNHEs play integral roles in regulating the luminal pH, processing, and trafficking of cargo along the secretory (Golgi and post-Golgi vesicles) and endocytic (early, recycling, and late endosomes) pathways, essential regulatory processes vital for neuronal development and plasticity. Given the complex morphology and compartmentalization of multipolar neurons, the contribution of eNHEs in maintaining optimal pH homeostasis and cargo trafficking is especially significant during periods of structural and functional development and remodeling. While the importance of eNHEs has been demonstrated in a variety of non-neuronal cell types, their involvement in neuronal function is less well understood. In this review, we will discuss their emerging roles in excitatory synaptic function, particularly as it pertains to cellular learning and remodeling. We will also explore their connections to neurodevelopmental conditions, including intellectual disability, autism, and attention deficit hyperactivity disorders. |
| first_indexed | 2024-12-12T23:10:56Z |
| format | Article |
| id | doaj.art-1500ff46b15248199dfdb11cf09c58c5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T23:10:56Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-1500ff46b15248199dfdb11cf09c58c52022-12-22T00:08:35ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-04-011310.3389/fphys.2022.892196892196Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental DisordersAndy Y. L. Gao0Andy Y. L. Gao1Etienne Lourdin-De Filippis2John Orlowski3R. Anne McKinney4Integrated Program in Neuroscience, McGill University, Montreal, QC, CanadaDepartment of Pharmacology & Therapeutics, McGill University, Montreal, QC, CanadaGraduate School of Engineering, Polytech Nice-Sophia, University of Nice Sophia, Antipolis, FranceDepartment of Physiology, McGill University, Montreal, QC, CanadaDepartment of Pharmacology & Therapeutics, McGill University, Montreal, QC, CanadaEndomembrane alkali cation (Na+, K+)/proton (H+) exchangers (eNHEs) are increasingly associated with neurological disorders. These eNHEs play integral roles in regulating the luminal pH, processing, and trafficking of cargo along the secretory (Golgi and post-Golgi vesicles) and endocytic (early, recycling, and late endosomes) pathways, essential regulatory processes vital for neuronal development and plasticity. Given the complex morphology and compartmentalization of multipolar neurons, the contribution of eNHEs in maintaining optimal pH homeostasis and cargo trafficking is especially significant during periods of structural and functional development and remodeling. While the importance of eNHEs has been demonstrated in a variety of non-neuronal cell types, their involvement in neuronal function is less well understood. In this review, we will discuss their emerging roles in excitatory synaptic function, particularly as it pertains to cellular learning and remodeling. We will also explore their connections to neurodevelopmental conditions, including intellectual disability, autism, and attention deficit hyperactivity disorders.https://www.frontiersin.org/articles/10.3389/fphys.2022.892196/fullendomembranesalkali cation/proton exchangerspH regulationsynaptic functionneurodevelopmental disordersautism |
| spellingShingle | Andy Y. L. Gao Andy Y. L. Gao Etienne Lourdin-De Filippis John Orlowski R. Anne McKinney Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders Frontiers in Physiology endomembranes alkali cation/proton exchangers pH regulation synaptic function neurodevelopmental disorders autism |
| title | Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders |
| title_full | Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders |
| title_fullStr | Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders |
| title_full_unstemmed | Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders |
| title_short | Roles of Endomembrane Alkali Cation/Proton Exchangers in Synaptic Function and Neurodevelopmental Disorders |
| title_sort | roles of endomembrane alkali cation proton exchangers in synaptic function and neurodevelopmental disorders |
| topic | endomembranes alkali cation/proton exchangers pH regulation synaptic function neurodevelopmental disorders autism |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.892196/full |
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