Physiological and pathophysiological insights of Nav1.4 and Nav1.5 comparison

Physiological and pathophysiological insights of Nav1.4 and Nav1.5 comparison

Mutations in Nav1.4 and Nav1.5 α-subunits have been associated with muscular and cardiac channelopathies, respectively. Despite intense research on the structure and function of these channels, a lot of information is still missing to delineate the various physiological and pathophysiological proces...

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Bibliographic Details
Main Authors: Gildas eLoussouarn, Damien eSternberg, Sophie eNicole, Céline eMarionneau, Françoise eLe Bouffant, Gilles eToumaniantz, Julien eBarc, Olfat eMalak, Véronique eFressart, Yann ePéréon, Isabelle eBaró, Flavien eCharpentier
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Pharmacology
Subjects:
Nav1.5
Nav1.4
Physiopathology
missense mutations
associated/regulatory proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00314/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00314/full

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