Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Poxvirus MVA Expressing SARS-CoV-2 S Protein Induces Robust Immunity and Protects Rhesus Macaques From SARS-CoV-2

Novel safe, immunogenic, and effective vaccines are needed to control the COVID-19 pandemic, caused by SARS-CoV-2. Here, we describe the safety, robust immunogenicity, and potent efficacy elicited in rhesus macaques by a modified vaccinia virus Ankara (MVA) vector expressing a full-length SARS-CoV-2...

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Bibliographic Details
Main Authors: Petra Mooij, Juan García-Arriaza, Patricia Pérez, Adrian Lázaro-Frías, Babs E. Verstrepen, Kinga P. Böszörményi, Daniella Mortier, Zahra Fagrouch, Gwendoline Kiemenyi-Kayere, Henk Niphuis, Roja Fidel Acar, Lisette Meijer, Marieke A. Stammes, Ivanela Kondova, Ernst J. Verschoor, Corine H. GeurtsvanKessel, Erwin de Bruin, Reina S. Sikkema, Joanna Luczkowiak, Rafael Delgado, Dolores Montenegro, Eugenia Puentes, Esteban Rodríguez, Willy M. J. M. Bogers, Gerrit Koopman, Mariano Esteban
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
COVID-19
spike
MVA vaccine
rhesus macaques
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.845887/full

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