Diabetes Mellitus in a Patient With Lafora Disease: Possible Links With Pancreatic β-Cell Dysfunction and Insulin Resistance

Diabetes Mellitus in a Patient With Lafora Disease: Possible Links With Pancreatic β-Cell Dysfunction and Insulin Resistance

Lafora disease (LD) is a rare autosomal recessive disorder characterized by progressive myoclonic epilepsy followed by continuous neurological decline, culminating in death within 10 years. LD leads to accumulation of insoluble, abnormal, glycogen–like structures called Lafora bodies (LBs). It is ca...

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Bibliographic Details
Main Authors: Ramona C. Nicolescu, Sara Al-Khawaga, Berge A. Minassian, Khalid Hussain
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pediatrics
Subjects:
Lafora disease
EPM2A
EPM2B/NHLRC1
insulin resistance
diabetes
glycogen metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fped.2018.00424/full

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https://www.frontiersin.org/article/10.3389/fped.2018.00424/full

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