Dual role of novel ingenol derivatives from Euphorbia tirucalli in HIV replication: inhibition of de novo infection and activation of viral LTR.

HIV infection is not cleared by antiretroviral drugs due to the presence of latently infected cells that are not eliminated with current therapies and persist in the blood and organs of infected patients. New compounds to activate these latent reservoirs have been evaluated so that, along with HAART...

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Bibliographic Details
Main Authors: Celina M Abreu, Sarah L Price, Erin N Shirk, Rodrigo D Cunha, Luiz F Pianowski, Janice E Clements, Amilcar Tanuri, Lucio Gama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4020785?pdf=render