Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure

Abstract Cells are exposed to oxidative stress and reactive metabolites every day. The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis. Although mechanisms describing the interacti...

Full description

Bibliographic Details
Main Authors: Steven Hiemstra, Mirjam Fehling-Kaschek, Isoude A. Kuijper, Luc J. M. Bischoff, Lukas S. Wijaya, Marcus Rosenblatt, Jeroen Esselink, Allard van Egmond, Jornt Mos, Joost B. Beltman, Jens Timmer, Bob van de Water, Daniel Kaschek
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10857-x

Internet

https://doi.org/10.1038/s41598-022-10857-x

Similar Items