The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases

Summary: Inflammasomes are multiprotein signaling complexes that activate the innate immune system. Canonical inflammasomes recruit and activate caspase-1, which then cleaves and activates IL-1β and IL-18, as well as gasdermin D (GSDMD) to induce pyroptosis. In contrast, non-canonical inflammasomes,...

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Bibliographic Details
Main Authors: Patrick M. Exconde, Claudia Hernandez-Chavez, Christopher M. Bourne, Rachel M. Richards, Mark B. Bray, Jan L. Lopez, Tamanna Srivastava, Marisa S. Egan, Jenna Zhang, William Yoo, Sunny Shin, Bohdana M. Discher, Cornelius Y. Taabazuing
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015930

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723015930

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