Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models

Human metapneumovirus infection of organoid-derived human bronchial epithelium represents cell tropism and cytopathology as observed in in vivo models

ABSTRACT Human metapneumovirus (HMPV), a member of the Pneumoviridae family, causes upper and lower respiratory tract infections in humans. In vitro studies with HMPV have mostly been performed in monolayers of undifferentiated epithelial cells. In vivo studies in cynomolgus macaques and cotton rats...

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Bibliographic Details
Main Authors: Pau Ribó-Molina, Stefan van Nieuwkoop, Anna Z. Mykytyn, Peter van Run, Mart M. Lamers, Bart L. Haagmans, Ron A. M. Fouchier, Bernadette G. van den Hoogen
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSphere
Subjects:
human metapneumovirus
organoids
primary cell cultures
tropism
cytopathology
Online Access:https://journals.asm.org/doi/10.1128/msphere.00743-23

Internet

https://journals.asm.org/doi/10.1128/msphere.00743-23

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