Pegylated Insulin-Like Growth Factor 1 attenuates Hair Cell Loss and promotes Presynaptic Maintenance of Medial Olivocochlear Cholinergic Fibers in the Cochlea of the Progressive Motor Neuropathy Mouse

Pegylated Insulin-Like Growth Factor 1 attenuates Hair Cell Loss and promotes Presynaptic Maintenance of Medial Olivocochlear Cholinergic Fibers in the Cochlea of the Progressive Motor Neuropathy Mouse

The progressive motor neuropathy (PMN) mouse is a model of an inherited motor neuropathy disease with progressive neurodegeneration. Axon degeneration associates with homozygous mutations of the TBCE gene encoding the tubulin chaperone E protein. TBCE is responsible for the correct dimerization of a...

Full description

Bibliographic Details
Main Authors: Linda Bieniussa, Baran Kahraman, Johannes Skornicka, Annemarie Schulte, Johannes Voelker, Sibylle Jablonka, Rudolf Hagen, Kristen Rak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Neurology
Subjects:
cochlea
microtubules
MOC fibers
hearing loss
pegylated insulin-like growth factor 1
outer hair cell (OHC)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.885026/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.885026/full

Similar Items