A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil

A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil

IntroductionThe prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%–10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data f...

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Main Authors: Leandro Jonata de Carvalho Oliveira, Amanda Muniz Rodrigues, Carolina de Bustamante Fernandes, Fernanda Orpinelli Ramos do Rego, Fernanda Christtanini Koyama, Andreza Karine de Barros Almeida Souto, Thaiana Aragão Santana, João Paulo Gonzaga de Faria, Marcela Lima Bulcão, Ivana Lucia de Oliveira Nascimento, Ana Carolina Branco Neves Silva, Isabela Pessoa Elias Gonçalves, Rayana Elias Maia, Renata Gondim Meira Velame de Azevedo, Layla Testa Galindo, Daniela Vianna Pachito, Adriana Cury, Mariano Gustavo Zalis, Bruno Lemos Ferrari, Bernardo Garicochea, Rodrigo Dienstmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Oncology
Subjects:
hereditary breast cancer
cancer genetics
germline genetic testing
multigene panel testing
Brazil
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1495605/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1495605/full

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