Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer

Optimized detection of homologous recombination deficiency improves the prediction of clinical outcomes in cancer

Abstract Homologous recombination DNA-repair deficiency (HRD) is a common driver of genomic instability and confers a therapeutic vulnerability in cancer. The accurate detection of somatic allelic imbalances (AIs) has been limited by methods focused on BRCA1/2 mutations and using mixtures of cancer...

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Main Authors: Fernando Perez-Villatoro, Jaana Oikkonen, Julia Casado, Anastasiya Chernenko, Doga C. Gulhan, Manuela Tumiati, Yilin Li, Kari Lavikka, Sakari Hietanen, Johanna Hynninen, Ulla-Maija Haltia, Jaakko S. Tyrmi, Hannele Laivuori, Panagiotis A. Konstantinopoulos, Sampsa Hautaniemi, Liisa Kauppi, Anniina Färkkilä
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00339-8

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https://doi.org/10.1038/s41698-022-00339-8

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