Ligands stimulating antitumour immunity as the next G-quadruplex challenge

Abstract G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on increasing the cell-killing potency. Nevertheless, no G4 binder has been shown yet to...

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Bibliographic Details
Main Authors: Giulia Miglietta, Jessica Marinello, Marco Russo, Giovanni Capranico
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12943-022-01649-y