PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a novel immunometabolic target by using a bioinf...

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Detalhes bibliográficos
Main Authors: Yimin Zheng, Yining Wang, Zhou Lu, Jinkai Wan, Lulu Jiang, Danjun Song, Chuanyuan Wei, Chao Gao, Guoming Shi, Jian Zhou, Jia Fan, Aiwu Ke, Lu Zhou, Jiabin Cai
Formato: Artigo
Idioma:English
Publicado em: Wiley 2023-10-01
Colecção:Advanced Science
Assuntos:
carcinogen metabolism
ferroptosis
hepatocellular carcinoma
immunotherapy
Acesso em linha:https://doi.org/10.1002/advs.202301928

Internet

https://doi.org/10.1002/advs.202301928

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