PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

PGAM1 Inhibition Promotes HCC Ferroptosis and Synergizes with Anti‐PD‐1 Immunotherapy

Abstract The combination of immunotherapy and molecular targeted therapy exhibits promising therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still unclear. Here, phosphoglycerate mutase 1 (PGAM1) is identified as a novel immunometabolic target by using a bioinf...

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Bibliographic Details
Main Authors: Yimin Zheng, Yining Wang, Zhou Lu, Jinkai Wan, Lulu Jiang, Danjun Song, Chuanyuan Wei, Chao Gao, Guoming Shi, Jian Zhou, Jia Fan, Aiwu Ke, Lu Zhou, Jiabin Cai
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:Advanced Science
Subjects:
carcinogen metabolism
ferroptosis
hepatocellular carcinoma
immunotherapy
Online Access:https://doi.org/10.1002/advs.202301928

Internet

https://doi.org/10.1002/advs.202301928

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