Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

DNA polymerase theta (Polθ)-mediated end joining (TMEJ) is, along with homologous recombination (HR) and non-homologous end-joining (NHEJ), one of the most important mechanisms repairing potentially lethal DNA double-strand breaks (DSBs). Polθ is becoming a new target in cancer research because it d...

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Bibliographic Details
Main Authors: Gabriela Barszczewska-Pietraszek, Małgorzata Drzewiecka, Piotr Czarny, Tomasz Skorski, Tomasz Śliwiński
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
Polθ inhibitors
anticancer treatment
DNA double-strand break repair
DNA repair enzyme
Online Access:https://www.mdpi.com/1422-0067/24/1/319

Internet

https://www.mdpi.com/1422-0067/24/1/319

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