The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

Multiple cross-sectional and longitudinal studies have shown that serum levels of the chemokine ligand 2 (CCL-2) are associated with type 1 diabetes (T1D), although the direction of effect differs. We assessed CCL-2 serum levels in a longitudinal cohort to clarify this association, combined with gen...

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Bibliographic Details
Main Authors: Paul MH. Tran, Sharad Purohit, Eileen Kim, Khaled bin Satter, Diane Hopkins, Kathleen Waugh, Fran Dong, Suna Onengut-Gumuscu, Stephen S. Rich, Marian Rewers, Jin-Xiong She
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Translational Autoimmunity
Subjects:
CCR2
CCL2
MCP1
T1D
DAISY
Autoimmune
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909021000472

Internet

http://www.sciencedirect.com/science/article/pii/S2589909021000472

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