Role of endothelin receptor antagonist; bosentan in cisplatin-induced nephrotoxicity in ovariectomized estradiol treated rats

Role of endothelin receptor antagonist; bosentan in cisplatin-induced nephrotoxicity in ovariectomized estradiol treated rats

Background: Endothelin-1 (ET-1) is a vasoconstrictor peptide that mediates cell proliferation, fibrosis, and inflammation. ET-1 has 2 receptors A and B. Objectives: The present study investigated whether administration of ET-1 receptor type A antagonist leads to protect cisplatin (CP) induced nephr...

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Bibliographic Details
Main Authors: Alieh Zahedi, Mehdi Nematbakhsh, Maryam Moeini, Ardeshir Talebi
Format: Article
Language:English
Published: Society of Diabetic Nephropathy Prevention 2015-10-01
Series:Journal of Nephropathology
Subjects:
cisplatin
estradiol
nephrotoxicity
bosentan
rat
Online Access:https://nephropathol.com/PDF/JNP-4-134.pdf

Internet

https://nephropathol.com/PDF/JNP-4-134.pdf

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