Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma

Peptains block retinal ganglion cell death in animal models of ocular hypertension: implications for neuroprotection in glaucoma

Abstract Ocular hypertension is a significant risk factor for vision loss in glaucoma due to the death of retinal ganglion cells (RGCs). This study investigated the effects of the antiapoptotic peptides peptain-1 and peptain-3a on RGC death in vitro in rat primary RGCs and in mouse models of ocular...

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Bibliographic Details
Main Authors: Mi-Hyun Nam, Dorota L. Stankowska, Gretchen A. Johnson, Rooban B. Nahomi, Mina B. Pantcheva, Ram H. Nagaraj
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05407-2

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https://doi.org/10.1038/s41419-022-05407-2

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