Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice

Abstract Foxo family transcription factors are critically involved in multiple processes, such as metabolism, quiescence, cell survival and cell differentiation. Although continuous, high activity of Foxo transcription factors extends the life span of some species, the involvement of Foxo proteins i...

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Bibliographic Details
Main Authors: Aurélie Durand, Nelly Bonilla, Théo Level, Zoé Ginestet, Amélie Lombès, Vincent Guichard, Mathieu Germain, Sébastien Jacques, Franck Letourneur, Marcio Do Cruzeiro, Carmen Marchiol, Gilles Renault, Morgane Le Gall, Céline Charvet, Agnès Le Bon, Bruno Martin, Cédric Auffray, Bruno Lucas
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45984-8

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https://doi.org/10.1038/s41467-024-45984-8

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