Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells

Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY, INSL5 levels are elevated by calorie restriction,...

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Bibliographic Details
Main Authors: Lawrence J. Billing, Christopher A. Smith, Pierre Larraufie, Deborah A. Goldspink, Sam Galvin, Richard G. Kay, Jonathan D. Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M. Gribble, Frank Reimann
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877818306136