Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

Carrier-free nanoprodrug for p53-mutated tumor therapy via concurrent delivery of zinc-manganese dual ions and ROS

Human cancers typically express a high level of tumor-promoting mutant p53 protein (Mutp53) with a minimal level of tumor-suppressing wild-type p53 protein (WTp53). In this regard, inducing Mutp53 degradation while activating WTp53 is a viable strategy for precise anti-tumor therapy. Herein, a new c...

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Bibliographic Details
Main Authors: Jinping Wang, Chang Qu, Xinyue Shao, Guoqiang Song, Jingyu Sun, Donghong Shi, Ran Jia, Hailong An, Hongjun Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-02-01
Series:Bioactive Materials
Subjects:
p53-mutated tumor therapy
Wild-type p53 protein
Carrier-free nanoprodrug
Mn-ZnO2 nanoparticle
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22002729

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http://www.sciencedirect.com/science/article/pii/S2452199X22002729

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