Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.

Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.

No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induc...

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Bibliographic Details
Main Authors: Andrew R Williams, Alexander D Douglas, Kazutoyo Miura, Joseph J Illingworth, Prateek Choudhary, Linda M Murungi, Julie M Furze, Ababacar Diouf, Olivo Miotto, Cécile Crosnier, Gavin J Wright, Dominic P Kwiatkowski, Rick M Fairhurst, Carole A Long, Simon J Draper
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002991&type=printable

Internet

https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002991&type=printable

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