Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression
Exercise is helpful to counteract obesity and the related complications, and positive effects are associated to a switch of muscle fibres to an oxidative type. Here, the authors show that sirtuin 6 overexpression in mice induces such a switch by modulating Sox6 and CREB signalling, suggesting that s...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29472-5 |