Current Insights Into the Maintenance of Structure and Function of Intervertebral Disc: A Review of the Regulatory Role of Growth and Differentiation Factor-5

Current Insights Into the Maintenance of Structure and Function of Intervertebral Disc: A Review of the Regulatory Role of Growth and Differentiation Factor-5

Intervertebral disc degeneration (IDD), characterized by conversion of genotypic and phenotypic, is a major etiology of low back pain and disability. In general, this process starts with alteration of metabolic homeostasis leading to ongoing inflammatory process, extracellular matrix degradation and...

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Bibliographic Details
Main Authors: Bin Lv, Weikang Gan, Zhangrong Cheng, Juntao Wu, Yuhang Chen, Kangchen Zhao, Yukun Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
intervertebral disc degeneration
growth and differentiation factor (GDF)
nucleus pulposus
extracellular matrix
mesenchymal stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.842525/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.842525/full

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