Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans
Zanthoxylum schinifolium Sieb. Et Zucc. (green pepper), a well-known traditional Chinese spice, recent studies found that the water extract of Z. schinifolium could significantly enhance the innate immune system, and Z. schinifolium peel polysaccharide (ZSPP) in the water extract is one of the activ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Acta Agriculturae Scandinavica. Section B, Soil and Plant Science |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09064710.2021.2012249 |
| _version_ | 1797684314641530880 |
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| author | Chengying Shan Chengjie Shu Wei Nie Yue Xu Shihong Ma Qiuhui Hu |
| author_facet | Chengying Shan Chengjie Shu Wei Nie Yue Xu Shihong Ma Qiuhui Hu |
| author_sort | Chengying Shan |
| collection | DOAJ |
| description | Zanthoxylum schinifolium Sieb. Et Zucc. (green pepper), a well-known traditional Chinese spice, recent studies found that the water extract of Z. schinifolium could significantly enhance the innate immune system, and Z. schinifolium peel polysaccharide (ZSPP) in the water extract is one of the active ingredients where antioxidant and anti-aging properties of ZSPP is yet to be determined. Caenorhabditis elegans was employed to see if ZSPP has anti-aging properties. After medication with ZSPP, the longevity, motility ability, and stress resilience of C. elegans were measured. We studied C. elegans brood growth and the insulin/insulin-like growth factor (IGF) signalling pathway to learn more about the mechanism of ZSPP's anti-aging action. According to statistical analysis of the experimental results, ZSPP therapy increased the longevity of C. elegans, as well as its motility capacity and stress tolerance. ZSPP was discovered to get a protective effect on UV-irradiated C. elegans in specific and ZSPP had no influence on C. elegans reproduction. However, after ZSPP therapy, the levels of age-1 and hcf-1 mRNA were lowered. In C. elegans, ZSPP has an anti-aging impact via the insulin/IGF signaling system, but it has the potential to evolve into a multifunctional diet in the long term. |
| first_indexed | 2024-03-12T00:27:52Z |
| format | Article |
| id | doaj.art-1540b1a0fced49d29540473297e229e3 |
| institution | Directory Open Access Journal |
| issn | 0906-4710 1651-1913 |
| language | English |
| last_indexed | 2024-03-12T00:27:52Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Acta Agriculturae Scandinavica. Section B, Soil and Plant Science |
| spelling | doaj.art-1540b1a0fced49d29540473297e229e32023-09-15T10:26:27ZengTaylor & Francis GroupActa Agriculturae Scandinavica. Section B, Soil and Plant Science0906-47101651-19132022-12-0172147648410.1080/09064710.2021.20122492012249Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegansChengying Shan0Chengjie Shu1Wei Nie2Yue Xu3Shihong Ma4Qiuhui Hu5College of Food Science and Technology, Nanjing Agricultural UniversityNanjing Institute for the Comprehensive Utilization of Wild PlantsNanjing Institute for the Comprehensive Utilization of Wild PlantsNanjing Institute for the Comprehensive Utilization of Wild PlantsNanjing Institute for the Comprehensive Utilization of Wild PlantsCollege of Food Science and Technology, Nanjing Agricultural UniversityZanthoxylum schinifolium Sieb. Et Zucc. (green pepper), a well-known traditional Chinese spice, recent studies found that the water extract of Z. schinifolium could significantly enhance the innate immune system, and Z. schinifolium peel polysaccharide (ZSPP) in the water extract is one of the active ingredients where antioxidant and anti-aging properties of ZSPP is yet to be determined. Caenorhabditis elegans was employed to see if ZSPP has anti-aging properties. After medication with ZSPP, the longevity, motility ability, and stress resilience of C. elegans were measured. We studied C. elegans brood growth and the insulin/insulin-like growth factor (IGF) signalling pathway to learn more about the mechanism of ZSPP's anti-aging action. According to statistical analysis of the experimental results, ZSPP therapy increased the longevity of C. elegans, as well as its motility capacity and stress tolerance. ZSPP was discovered to get a protective effect on UV-irradiated C. elegans in specific and ZSPP had no influence on C. elegans reproduction. However, after ZSPP therapy, the levels of age-1 and hcf-1 mRNA were lowered. In C. elegans, ZSPP has an anti-aging impact via the insulin/IGF signaling system, but it has the potential to evolve into a multifunctional diet in the long term.http://dx.doi.org/10.1080/09064710.2021.2012249zanthoxylum schinifolium peel polysaccharideanti-agingcaenorhabditis eleganslifespanstress resistanceuv-irradiated |
| spellingShingle | Chengying Shan Chengjie Shu Wei Nie Yue Xu Shihong Ma Qiuhui Hu Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans Acta Agriculturae Scandinavica. Section B, Soil and Plant Science zanthoxylum schinifolium peel polysaccharide anti-aging caenorhabditis elegans lifespan stress resistance uv-irradiated |
| title | Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans |
| title_full | Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans |
| title_fullStr | Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans |
| title_full_unstemmed | Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans |
| title_short | Anti-aging effect of polysaccharides from the peel of Zanthoxylum schinifolium Sieb. et Zucc. on the nematode Caenorhabditis elegans |
| title_sort | anti aging effect of polysaccharides from the peel of zanthoxylum schinifolium sieb et zucc on the nematode caenorhabditis elegans |
| topic | zanthoxylum schinifolium peel polysaccharide anti-aging caenorhabditis elegans lifespan stress resistance uv-irradiated |
| url | http://dx.doi.org/10.1080/09064710.2021.2012249 |
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