Effects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2

Effects of cancer-associated point mutations on the structure, function, and stability of isocitrate dehydrogenase 2

Abstract Mutations in isocitrate dehydrogenase (IDH) are frequently found in low-grade gliomas, secondary glioblastoma, chondrosarcoma, acute myeloid leukemias, and intrahepatic cholangiocarcinoma. However, the molecular mechanisms of how IDH2 mutations induce carcinogenesis remain unclear. Using ov...

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Bibliographic Details
Main Authors: Xiang Chen, Peipei Yang, Yue Qiao, Fei Ye, Zhipeng Wang, Mengting Xu, Xiaowang Han, Li Song, Yuehong Wu, Wen-Bin Ou
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23659-y

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https://doi.org/10.1038/s41598-022-23659-y

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