Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

Gene recoding by synonymous mutations creates promiscuous intragenic transcription initiation in mycobacteria

ABSTRACT Each genome encodes some codons more frequently than their synonyms (codon usage bias), but codons are also arranged more frequently into specific pairs (codon pair bias). Recoding viral genomes and yeast or bacterial genes with non-optimal codon pairs has been shown to decrease gene expres...

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Bibliographic Details
Main Authors: Nuri K. Hegelmeyer, Lia A. Parkin, Mary L. Previti, Joshua Andrade, Raditya Utama, Richard J. Sejour, Justin Gardin, Stephanie Muller, Steven Ketchum, Alisa Yurovsky, Bruce Futcher, Sara Goodwin, Beatrix Ueberheide, Jessica C. Seeliger
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
recoding
codon pair bias
transcription
Mycobacterium
tuberculosis
translation
Online Access:https://journals.asm.org/doi/10.1128/mbio.00841-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00841-23

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