A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis

A MAPS Vaccine Induces Multipronged Systemic and Tissue-Resident Cellular Responses and Protects Mice against Mycobacterium tuberculosis

ABSTRACT Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide. To date, the mainstay of vaccination involves the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG), a live-attenuated vaccine that confers protection against extrapulmonary disease in infants and childr...

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Bibliographic Details
Main Authors: Joanne M. O’Hara, Shoko Wakabayashi, Noman Siddiqi, Elaine Cheung, Gregory H. Babunovic, Claudette M. Thompson, Ying-Jie Lu, Eric J. Rubin, Richard Malley, Fan Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
B cell
Mycobacterium tuberculosis
T cell
tuberculosis
vaccine
Online Access:https://journals.asm.org/doi/10.1128/mbio.03611-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03611-22

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