Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs.

Binding mechanism of oseltamivir and influenza neuraminidase suggests perspectives for the design of new anti-influenza drugs.

Oseltamivir is a widely used influenza virus neuraminidase (NA) inhibitor that prevents the release of new virus particles from host cells. However, oseltamivir-resistant strains have emerged, but effective drugs against them have not yet been developed. Elucidating the binding mechanisms between NA...

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Bibliographic Details
Main Authors: Jiaye Tao, Heping Wang, Wenjian Wang, Na Mi, Wei Zhang, Qiujia Wen, Jiajing Ouyang, Xinyun Liang, Min Chen, Wentao Guo, Guoming Li, Jun Liu, Hanning Zhao, Xin Wang, Xuemeng Li, Shengjun Feng, Xinguang Liu, Zhiwei He, Zuguo Zhao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010343

Internet

https://doi.org/10.1371/journal.pcbi.1010343

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