Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

Summary: mTORC1 is aberrantly activated in cancer and in the genetic tumor syndrome tuberous sclerosis complex (TSC), which is caused by loss-of-function mutations in the TSC complex, a negative regulator of mTORC1. Clinically approved mTORC1 inhibitors, such as rapamycin, elicit a cytostatic effect...

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Bibliographic Details
Main Authors: Molly C. McNamara, Aaron M. Hosios, Margaret E. Torrence, Ting Zhao, Cameron Fraser, Meghan Wilkinson, David J. Kwiatkowski, Elizabeth P. Henske, Chin-Lee Wu, Kristopher A. Sarosiek, Alexander J. Valvezan, Brendan D. Manning
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:iScience
Subjects:
Biological sciences
Cancer
Cell biology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222017308

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222017308

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