Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment

The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified usin...

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Bibliographic Details
Main Authors: Sing Teang Kong, Hai-Shu Lin, Jianhong Ching, Huiqing Xie, Paul C. Ho
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
dried blood spot (DBS)
gas chromatography/mass spectrometry (GC/MS)
metabolomics
pharmacokinetics
valproate
Online Access:https://www.mdpi.com/1422-0067/23/13/7083

Internet

https://www.mdpi.com/1422-0067/23/13/7083

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