Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment
The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An established approach using dried blood spots (DBS) as sample matrices for gas chromatography/mass spectrometry-based metabolomics profiling was modified usin...
Main Authors: | Sing Teang Kong, Hai-Shu Lin, Jianhong Ching, Huiqing Xie, Paul C. Ho |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-06-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/13/7083 |
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