Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in <i>LMOD2</i> Gene Causing Infantile Dilated Cardiomyopathy

Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in <i>LMOD2</i> Gene Causing Infantile Dilated Cardiomyopathy

As an essential component of the sarcomere, actin thin filament stems from the Z-disk extend toward the middle of the sarcomere and overlaps with myosin thick filaments. Elongation of the cardiac thin filament is essential for normal sarcomere maturation and heart function. This process is regulated...

Full description

Bibliographic Details
Main Authors: Reiri Sono, Tania M. Larrinaga, Alden Huang, Frank Makhlouf, Xuedong Kang, Jonathan Su, Ryan Lau, Valerie A. Arboleda, Reshma Biniwale, Gregory A. Fishbein, Negar Khanlou, Ming-Sing Si, Gary M. Satou, Nancy Halnon, UCLA Congenital Heart Defects-BioCore Faculty, Glen S. Van Arsdell, Carol C. Gregorio, Stanly Nelson, Marlin Touma
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
<i>LMOD2</i>
leiomodins
heart maturation
thin filament
sarcomere
whole-exome sequencing
Online Access:https://www.mdpi.com/2073-4409/12/11/1455

Internet

https://www.mdpi.com/2073-4409/12/11/1455

Similar Items