A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail <i>Conus fergusoni</i>, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors

A Novel Dimeric Conotoxin, FrXXA, from the Vermivorous Cone Snail <i>Conus fergusoni</i>, of the Eastern Pacific, Inhibits Nicotinic Acetylcholine Receptors

We isolated a new dimeric conotoxin with inhibitory activity against neuronal nicotinic acetylcholine receptors. Edman degradation and transcriptomic studies indicate a homodimeric conotoxin composed by two chains of 47 amino acid in length. It has the cysteine framework XX and 10 disulfide bonds. A...

Full description

Bibliographic Details
Main Authors: Ximena C. Rodriguez-Ruiz, Manuel B. Aguilar, Mónica A. Ortíz-Arellano, Helena Safavi-Hemami, Estuardo López-Vera
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Toxins
Subjects:
alpha d-conotoxin
dimeric-peptides
nAChR
<i>Conus</i> snails
<i>Conus fergusoni</i>
Online Access:https://www.mdpi.com/2072-6651/14/8/510

Internet

https://www.mdpi.com/2072-6651/14/8/510

Similar Items