Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

Abstract Background Auto-antibodies (auto-Abs) neutralizing type I interferons (IFN) have been found in about 15% of critical cases COVID-19 pneumonia and less than 1% of mild or asymptomatic cases. Determining whether auto-Abs influence presentation and outcome of critically ill COVID-19 patients c...

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Main Authors: Romain Arrestier, Paul Bastard, Thibaut Belmondo, Guillaume Voiriot, Tomas Urbina, Charles-Edouard Luyt, Adrian Gervais, Lucy Bizien, Lauriane Segaux, Mariem Ben Ahmed, Raphaël Bellaïche, Taï Pham, Zakaria Ait-Hamou, Damien Roux, Raphael Clere-Jehl, Elie Azoulay, Stéphane Gaudry, Julien Mayaux, Nicolas Fage, Hafid Ait-Oufella, Elsa Moncomble, Mélodie Parfait, Karim Dorgham, Guy Gorochov, Armand Mekontso-Dessap, Florence Canoui-Poitrine, Jean-Laurent Casanova, Sophie Hue, Nicolas de Prost
Format: Article
Language:English
Published: SpringerOpen 2022-12-01
Series:Annals of Intensive Care
Subjects:
COVID-19
Interferon
Auto-antibodies
Acute respiratory distress syndrome
Online Access:https://doi.org/10.1186/s13613-022-01095-5

Internet

https://doi.org/10.1186/s13613-022-01095-5

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