DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells.

DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells.

DNA methylation (DNAme; 5-methylcytosine, 5mC) plays an essential role in mammalian development, and the 5mC profile is regulated by a balance of opposing enzymatic activities: DNA methyltransferases (DNMTs) and Ten-eleven translocation dioxygenases (TETs). In mouse embryonic stem cells (ESCs), de n...

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Bibliographic Details
Main Authors: Takamasa Ito, Musashi Kubiura-Ichimaru, Yuri Murakami, Aaron B Bogutz, Louis Lefebvre, Isao Suetake, Shoji Tajima, Masako Tada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262277&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262277&type=printable

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