Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity

TAX2 peptide is a cyclic peptide that acts as an orthosteric antagonist for thrombospondin-1 (TSP-1) interaction with CD47. TAX2 was first described for its anti-angiogenic activities and showed anti-cancer efficacy in numerous preclinical models. Here, we aimed at providing an extensive molecular c...

Full description

Bibliographic Details
Main Authors: Albin Jeanne, Thomas Sarazin, Magalie Charlé, Catherine Moali, Caroline Fichel, Camille Boulagnon-Rombi, Maïté Callewaert, Marie-Christine Andry, Eric Diesis, Frédéric Delolme, Damien Rioult, Stéphane Dedieu
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
ovarian cancer
TSP-1
CD47
peptide
immunotherapy
Online Access:https://www.mdpi.com/2072-6694/13/19/5019

Internet

https://www.mdpi.com/2072-6694/13/19/5019

Similar Items