Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1

Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1

Angiogenesis is one hallmark of cancer. Vascular endothelial growth factor (VEGF) is a known inducer of angiogenesis. Many patients benefit from antiangiogenic therapies, which however have limitations. Although VEGF is overexpressed in most tumors, different VEGF isoforms with distinct angiogenic p...

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Bibliographic Details
Main Authors: Kay-Dietrich Wagner, Mounir El Maï, Michael Ladomery, Tareg Belali, Nathalie Leccia, Jean-François Michiels, Nicole Wagner
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
VEGF isoforms
splicing factors
endothelium
transcriptional regulation
Wilms’ tumor suppressor Wt1
Online Access:http://www.mdpi.com/2073-4409/8/1/41

Internet

http://www.mdpi.com/2073-4409/8/1/41

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