Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging

Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4+ T Cells in Aging

Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4+ T lymphocytes in the elderly. In this proof of principle study, it is investigated whether the transfer of functional mitochondria...

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Bibliographic Details
Main Authors: Colwyn A. Headley, Shalini Gautam, Angelica Olmo‐Fontanez, Andreu Garcia‐Vilanova, Varun Dwivedi, Anwari Akhter, Alyssa Schami, Kevin Chiem, Russell Ault, Hao Zhang, Hong Cai, Alison Whigham, Jennifer Delgado, Amberlee Hicks, Philip S. Tsao, Jonathan Gelfond, Luis Martinez‐Sobrido, Yufeng Wang, Jordi B. Torrelles, Joanne Turner
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Advanced Science
Subjects:
adaptive immunity
aging immunology
CD4+ T cells
immunometabolism
mitochondrial dysfunction
Online Access:https://doi.org/10.1002/advs.202303664

Internet

https://doi.org/10.1002/advs.202303664

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