Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

Nedd4/Rsp5 family E3 ligases mediate numerous cellular processes, many of which require the E3 ligase to interact with PY motif containing adaptor proteins. Several arrestin-related trafficking adaptors (ARTs) of Rsp5 were self-ubiquitinated for activation, but the regulation mechanism remains elusi...

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Bibliographic Details
Main Authors: Lu Zhu, Qing Zhang, Ciro D Cordeiro, Sudeep Banjade, Richa Sardana, Yuxin Mao, Scott D Emr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
K63 di-ubiquitin
Nedd4/Rsp5
E3 ligase
adaptor
ubiquitination
Online Access:https://elifesciences.org/articles/77424

Internet

https://elifesciences.org/articles/77424

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