Redox-Sensitive Delivery of Doxorubicin from Nanoparticles of Poly(ethylene glycol)-Chitosan Copolymer for Treatment of Drug-Resistant Oral Cancer Cells

Redox-Sensitive Delivery of Doxorubicin from Nanoparticles of Poly(ethylene glycol)-Chitosan Copolymer for Treatment of Drug-Resistant Oral Cancer Cells

Reactive oxygen species (ROS)-sensitive polymer nanoparticles were synthesized for tumor targeting of an anticancer drug, doxorubicin (DOX). For this purpose, chitosan-methoxy poly(ethylene glycol) (mPEG) (ChitoPEG)-graft copolymer was synthesized and then DOX was conjugated to the backbone of chito...

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Bibliographic Details
Main Authors: Kaengwon Yoon, Seunggon Jung, Jaeyoung Ryu, Hong-Ju Park, Hee-Kyun Oh, Min-Suk Kook
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
ROS-sensitive drug delivery
nanoparticles
drug-resistant
doxorubicin
oral squamous carcinoma cells
Online Access:https://www.mdpi.com/1422-0067/24/18/13704

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https://www.mdpi.com/1422-0067/24/18/13704

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