Pharmacological effects of mTORC1/C2 inhibitor in a preclinical model of NASH progression

Pharmacological effects of mTORC1/C2 inhibitor in a preclinical model of NASH progression

Knowledge of the benefits of mTOR inhibition concerning adipogenesis and inflammation has recently encouraged the investigation of a new generation of mTOR inhibitors for non-alcoholic steatohepatitis (NASH). We investigated whether treatment with a specific mTORC1/C2 inhibitor (Ku-0063794; KU) exer...

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Bibliographic Details
Main Authors: Mahak Arora, Zuzana Pavlíková, Tomáš Kučera, Petr Kozlík, Tijana Šopin, Tomáš Vacík, Matej Ľupták, Matthias Duda, Ondřej Slanař, Nikolina Kutinová Canová
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ku-0063794
atherogenic diet
lipotoxicity
mTOR
non-alcoholic steatohepatitis
mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012453

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http://www.sciencedirect.com/science/article/pii/S0753332223012453

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