Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

Abstract Background Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently muta...

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Main Authors: Helena Gbelcová, Silvie Rimpelová, Zdeněk Knejzlík, Jana Šáchová, Michal Kolář, Hynek Strnad, Vanda Repiská, Walter Cosimo D’Acunto, Tomáš Ruml, Libor Vítek
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Lipids in Health and Disease
Subjects:
Farnesyl pyrophosphate
Gene expression
Geranylgeranyl pyrophosphate
HMG-CoA reductase inhibitors
Isoprenoids
K-Ras oncogene
Online Access:http://link.springer.com/article/10.1186/s12944-017-0641-0

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http://link.springer.com/article/10.1186/s12944-017-0641-0

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