NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis

NIMBus: a negative binomial regression based Integrative Method for mutation Burden Analysis

Abstract Background Identifying frequently mutated regions is a key approach to discover DNA elements influencing cancer progression. However, it is challenging to identify these burdened regions due to mutation rate heterogeneity across the genome and across different individuals. Moreover, it is k...

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Bibliographic Details
Main Authors: Jing Zhang, Jason Liu, Patrick McGillivray, Caroline Yi, Lucas Lochovsky, Donghoon Lee, Mark Gerstein
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Bioinformatics
Subjects:
Somatic mutation burden
Mutation rate heterogeneity
Mutation rate estimation
Mutation count overdispersion
Online Access:http://link.springer.com/article/10.1186/s12859-020-03758-1

Internet

http://link.springer.com/article/10.1186/s12859-020-03758-1

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